Monday, July 7, 2008

20 - lupus pernio (cutaneous sarcoidosis)



Lupus Pernio is one of the few cutaneous manifestations that are characteristic of sarcoidosis. Lesions are chronic, indurated papules or plaques that affect the mid-face, particularly the alar rim of the nose. Even a few small papules in this location may be associated with granulomatous infiltration of the nasal mucosa and upper respiratory tract, resulting in masses, ulcerations, or even life-threatening airway obstruction.

Lupus pernio is a chronic raised indurated (hardened) lesion of the skin, often purplish in color. It resembles frostbite as it is seen on ears, cheeks, lips, nose, hands, fingers, and forehead. It is most often associated with sarcoidosis. Microscopically, it resembles Lupus vulgaris. Biopsy shows granulomatous infiltration.

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