The desmogleins are a family of cadherins consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the formation of desmosomes that join cells to one another.
The main defect in the bullous disorders of the skin is the desmogleins. A defect in these desmogleins causes separation of epidermal cells with destruction of desmoglein . as a result large bullae are formed.
This process is otherwise called acantholysis .
Desmogleins are targeted in the autoimmune disease pemphigus ( a type of bullous disorders of skin ) .
A defect in desmoglein 1 causes --- pemphigus foliaceous
A defect in desmoglein 2 causes --- pemphigus vegitans
A defect in desmoglein 3 causes --- pemphigus vulgaris .
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